Antimicrobial Silver Nanoparticles for wounds treatment

Pseudomonas aeruginosa is an opportunistic pathogen which cause a wide range of infections, especially in people with weak immunity and people with severe burns. Patients with burns are more able to acquire P. aeruginosa infection of the burn wound with subsequent septicaemia and death because at the time of burn injury, both the normal skin barrier and many of the systemic host defense mechanisms get disrupts, which increases the chances to make skin susceptible to microbial colonization resulting in development of burn wound.

P. aeruginosa is naturally resistant to a significant number of antimicrobials and this resistance of P. aeruginosa to commonly used therapeutic agents has increased in recent years. In case of burn patients, the invasive microbial infections remain active on burned skin until complete epithelial skin layer repair has occurred. Microbial drug resistant is emerged as a major problem in health care industry as microbes plays a role in the change of their genetic structure with metabolism to acquire resistant against the drugs which are probably used in the treatment of infectious disease.

There is a historical background of inhibitory action of silver compounds and silver ions. That’s why it is applied as a useful therapeutic agent for preventing wound infections. On bacterial cells, there is a strong interaction of silver with thiol (-SH) groups present in key respiratory enzymes in bacteria which results in inhibition of bacterial growth. Whereas, Nano crystalline silver shows the most effective inhibitory action with a fast inhibition rate.

Silver has a low toxicity for humans, silver ions are effective antimicrobial & a suitable & attractive additive also in wound dressings, packaging materials, and anti-fouling & antibacterial surface coatings.

How does it work?

Silver (Ag) is a natural antimicrobial agent which must be in contact with the cut or burn to work effectively. No other antimicrobial ointment should be used as it will interfere with the silver’s antimicrobial properties.

Silver inhibits bacterial growth by rupturing the cell membrane, binding to the DNA of cells, and blocking the metabolism of the bacteria. There are multiple means of silver to fight the bacteria, In this condition, it is difficult for the bacteria to become resist.

AgSterilized Technology

It is a technique which can provide you hygiene or we can say surfaces without contamination. No need of applying sterilization techniques. Silver nanoparticles (AgNps) are superior material to introduce as a sterilized solution for all kind of unhygienic conditions. They have gained lot of attention for their antimicrobial activity because they are more effective in terms of minimum inhibitory concentration (MIC) than ionic Silver (Ag+). Due to these antimicrobial properties, their incorporation into medical devices and other health related products promote higher preventive infection control.

Bandages with nano-silver are used for first-aid treatment, healing of wounds and burns of different etiology, including those with high infection risk. Silver contained in the bandages has an antimicrobial impact on the wound, reduces the first stage of wound treatment, and speeds up the healing process and no need to use medications and antiseptic agents. It is a solution for people prone to allergic reactions to pharmaceuticals.

Nanosilver gel/ointment cream for topical treatment of burns

Silver compounds with antimicrobial activity are used to prevent infective complications in burn wounds. Among them, mafenide acetate 11.2% cream (e.g., sulfamylon) is one of the oldest effective topical antimicrobial agents; it has broad spectrum of antimicrobial activity, with some antifungal properties. But, mafenide cream is toxic to epithelial cells and fibroblasts and it can cause an allergic skin rash.

Silver sulfadiazine (SSD) is painless on application, has high patient acceptance, and is easy to use with or without dressing. However, it is not the ideal topical antimicrobial, because deep-dermal wounds usually heal slowly and there is suspicion that SSD may delay the process further, and bacterial resistance to SSD has also been reported. Thus there is a need to continue the search for a superior antimicrobial with desirable effects on burn wound healing.

Pure form of silver can be utilized as a topical treatment for burn wounds. The nanometer-sized particles are metastable in nature and thus more reactive than bulk form. The high surface to volume ratio of the nanoparticles is another advantage as it allows the particles to remain effective even at a very low concentration. Thus minimizes the chance for tissue toxicity.

Nano-crystalline silver have antibacterial as well as antifungal properties. It disrupt bacterial cell wall, block DNA replication and deactivate vital enzymes of bacterial respiratory system. Thus, nano-crystalline silver can be an effective barrier against microbial invasion and significantly decrease the risk of infection. Within 10 days of dressing with nano-silver (AgNP), patient shows significant clinical improvement and within 23 days, patient had complete wound healing.

Advantages of “Agsterilized Nanosilver”

  • They have high antimicrobial activity. In particular, they are capable to suppress microorganisms or their modified forms, which are the most adapted to external impact.

  • They have the full spectrum of antimicrobial effect (bacteria, viruses, fungi) and suppression of pathogenic micro flora (spores).

  • They have no chlorine containing components.

  • They ensure health safety of personnel and patients at recommended treatment regimes.

  • They are ecologically safe. They do not pollute environment with harmful chemical compositions.

Products

1) Liquid Nano Silver: Aqueous dispersion of colloidal silver

Liquid Nano Silver is having the particle size of 15 nm and is totally miscible in water. It can be used as an additive to any water based coatings. Liquid silver is available in two concentrations

i) W10 (100,000 ppm nano silver solution in water)

ii) W50 (450,000 ppm nano silver solution in water)

2) Nano Silver Fibers

Nano Silver impregnated fibers having Nanosilver @ 400 ppm in various polymers like PET, NYLON etc. are available, which can be successfully blended with Cotton, Viscose staple fibers, Rayon etc. for making various kind of Antimicrobial textiles.

Contact Us for Agsterlized Nanosilver

You can easily purchase excellent quality nano materials at great prices. To Place an order download our order form and send to us. All materials are dispatched though registered couriers and post. You can also request for a quote by mailing us at info@reinste.com

Contact: +91 120 4781212,4781217, 4781230 or 91 9810662669. We invite you to contact us for further information about our company and our capabilities. At Reinste Nano Ventures, we could be glad to be of service to you. We look forward to your suggestions and feedback.

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